Fat increases satiety....(hmmm, right?)

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Lard Lesson: Why Fat Lubricates Your Appetite: Scientific American

Interesting read, particularly for those of us who have been told (or are convinced) fat increases satiety.

Curious to hear other's thoughts, as this article was somewhat surprising to me.

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Re: Fat increases satiety....(hmmm, right?)

"Taking time off from a healthy diet to eat most fast foods may have consequences that last for some days, even after one resumes the healthy diet,"

Hmm...."fast foods". They must mean lots of fat in combination with carbs?

[liv]

Re: Fat increases satiety....(hmmm, right?)

Try reading the actual study

Journal of Clinical Investigation -- Palmitic acid mediates hypothalamic insulin resistance by altering PKC-θ subcellular localization in rodents
Study was done on rats and mice (genetically modiefied ones it looks like) and they high fat as 40%

This is what they concluded

Results

Palmitic acid, regardless of obesity, impairs leptin and insulin’s ability to regulate food intake and body weight and decreases activation of PI3K. In agreement with previous reports (10, 29, 30), we first confirmed that maintenance on a high-fat–saturated (HFS) diet reduces hypothalamic insulin and leptin sensitivity. Rats fed a diet high in saturated fat (40% of calories from HFS diet) or a diet high in oleic acid (40% of calories from oleic acid diet) for 3 months weighed more and had more body fat (Table 1) than rats fed a matched low-fat control diet (for nutrient information, see ref. 31 and Table 2). The fatty acid composition of the HFS diet was 10% myristate/27% palmitate/12% stearate/25% oleate. The composition of the oleic acid diet was 11% palmitate/ 70% oleate/13% linoleate. It is important to note the HFS contains a high amount of saturated fatty acids, but it also contains unsaturated fatty acids, including oleic acid. The critical variable we are testing is the role of palmitate, and the HFS diet has substantially more palmitate than the oleic acid–enriched diet. The HFS diet–fed rats have an attenuated anorexic response to third-ventricular (i.c.v.) insulin (Figure 1A) compared with the animals maintained on the low-fat or the high-fat oleic acid diets. To assess whether the failure of insulin to reduce body weight in HFS diet–fed rats was associated with reduced insulin-induced phosphorylation of AKT (p-AKT), insulin was infused i.c.v. and rats were sacrificed 10 minutes later. Insulin-induced p-AKT was assessed in medial basal hypothalamic tissue (the brain was rapidly removed, snap frozen, and a ~70-mg wedge of hypothalamus was excised caudal to the mammillary bodies, rostral to the optic chiasm, lateral to the optic tract, and superior to the apex of the hypothalamic third ventricle). Animals maintained on the HFS diet have reduced insulin-induced p-AKT relative to those on the low-fat and the oleic acid diets (Figure 1, B and C), implying that maintenance on a saturated fatty acid–diet, which is high in palmitic acid, but not a diet high in oleic acid, attenuates insulin activity and induces insulin resistance.

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Re: Fat increases satiety....(hmmm, right?)

Try reading the actual study

No thanks.

So, what's your non-scientific take away from this for us mere mortals whose eyes glaze over at the study? (other than the obvious GM mice vs. human comparison)...

[Suzanne_H]

Re: Fat increases satiety....(hmmm, right?)

All I know is my belly doesn't tell me FEED ME all the darned time like it did when I was trying to quiet the urges with more sugar and more starch. 'Nuff said. This WOE works for me!

[liv]

Re: Fat increases satiety....(hmmm, right?)

What I see is that the so called high ffat fed "rad were fed very little fat (compared to what we eat), lots of carbohydrates, never allowed to experience ketosis. I am not sure that this proves squat about anything.
I saw one paleo person write in his comments that if this research applied to human being all our early ancestors would have been really fat and we consequently are very thin.

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Re: Fat increases satiety....(hmmm, right?)

What I see is that the so called high ffat fed "rad were fed very little fat (compared to what we eat), lots of carbohydrates, never allowed to experience ketosis. I am not sure that this proves squat about anything.

Gotcha. That was my layman's reaction, too. Lots of fat with lots of carbs doesn't prove much, regardless of the hypothesis.